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A study on the effects of beer on the efficacy of antimalarial drug administered 1hour before beer consumption in albino rats

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Abstract

The study assessed the effect of beer consumption on the efficacy of antimalaria drug administered one hour before beer in albino rat. Forty-four albino wister rats randomized into nine groups of 3 animals each were treared with atmal-plus, Fasnmet, Camosunate, the control group treated with feed and water only and alcohol only. A locally selected brand of beer for forty days were treated with graded concentrations of the  selected  beer. The mean percentage parasitemia  treated using  standard methods. Results showed that groups treated with Atmal + beer were significantly (p0.05) reduced compared to the negative control and significantly (p0.05) decreased compared  to the Atmal + no beer. And significantly (p0.05) decreased when compared to the Fanmet + beer, and Camosunate + beer with the negative control. In the activities of serum alanine and aspartate amino transferase, alkaline phosphates, haemoglobin and red blood cell count, the showed that the mean serum liver enzyme activities, RBC and HB were significantly (p0.05)elevated when compared to the normal control. The findings suggests that intake of antimalarial drugs 1hour before beer consumption can pose a negative effect on the drug bio-availability of the drug thereby, reducing its effectiveness.

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