This research work was designed to examine the effect of treasury single account on polytechnic administration in Nigeria with Federal University, Lokoja as the case study. The specific objectives of the study is to find out the effect of treasury single account on prompt/timely payments for expenditures in government owned polytechnics in Nigeria. It also find out the positive and negative implications of treasury single account on kogi state polytechnic. Four research questions guided this study. A descriptive survey research design was used for the study. The population of this study comprises both Senior and Junior staff of Kogi state Polytechnic lokoja, which is 500. Out of the 222 questionnaire administered 120 were filled and returned representing 54% response rate. Statistical tools used for the analysis were tables and percentage. The major finding of the study is that TSA implementation slow down release of funds by state and federal government to tertiary institutions and that since the commencement of TSA, payments for teaching and learning materials have become slow. TSA implementation slows down payments for environmental sanitation expenses in the polytechnic. A major findings was that bureaucratic bottlenecks in accessing approved funds have increased since TSA implementation commenced. A number of recommendations were put forward for the urgent need of state and federal government to review implementation of treasury single account especially as it relates to inclusion of service oriented organisations such as the university.