This research work empirically explored the impact of infectious epidemic on the banking Industry – a case study of corona virus disease. The objectives of this study were to examine the level of coronavirus disease in Nigeria, investigate the impact of coronavirus disease on banking transactions in Nigeria. The scope of the study is banks in Nigeria, The infectious disease transmission mechanism theory was used as a framework. The research design used for this study is survey, the population targeted for this study consists of all first bank across the country. 40 first bank branches including the headquarter were used as sample size and cluster sampling technique was applied. Instrument used for this study is the questionnaire. Data collected were collected from primary sources. From the analysis of the data, the findings show that the level of coronavirus disease in Nigeria is average, coronavirus disease has an effect on the level of banking transactions in Nigeria. Following the findings, it was recommended that measures should be devised to curb the spread of the virus and vaccine created so as to prevent further hinge on banking activities, banks should devise a means to function as normal even if it entails making use of online means. The study concludes that coronavirus disease has a negative effect on the banking community. Keywords: coronavirus disease, banking industry, Nigeria.